Beschrijving
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The Juliá-Colonna epoxidation is an asymmetric poly-leucine catalyzed nucleophilic epoxidation of electron deficient olefins in a triphasic system. The reaction was first developed by Sebastian Juliá in 1980, and the first article was followed up in 1982 with further elaboration by both Juliá and Stefano Colonna. In the original triphasic protocol, the chalcone substrate is soluble in the organic phase, generally toluene or carbon tetrachloride. The alkaline hydrogen peroxide oxidant is soluble primarily in the aqueous phase, and the reaction occurs at the insoluble polymer layer at the interface of the two phases. Alternative biphasic and monophasic protocols have been developed with increased substrate accessibility and reaction rate.